Course title: Neural Circuits for Navigation: Anatomy, Physiology, and Computational Methods
Course outline:
Dr. Eric Denovellis is a computational neuroscientist, whose work
specializes on interpretable algorithms and tools to decode, categorize, and
visualize neural representations, particularly in the hippocampal circuit. He
is also the co-developer of an open-source neural data management and analysis
platform built on a neural data standard, Neuro data Without Borders (NWB), and
Data Joint. The course will be offered on-site at NCBS. Lectures will be held in
person.
2 credit course (total contact hours: 20; total TA hours: 10)
Lecture 1:
Hippocampal anatomy and physiology [1.5 hour] – Abhilasha
Lecture 2: Entorhinal cortex anatomy and physiology [1.5 hour] –
Abhilasha
Lecture 3: Septo-hippocampal & septo-cortical connections [1.5 hour]
– Abhilasha
Lecture 4-5-6-7/ Open data use and visualization [4 hours] –
Abhilasha/Eric
- Common data standards in neuroscience and their use (NWB)
- Visualize and characterize LFP
- Visualize and characterize spikes
- Visualize and characterize properties of stimulus (position, sound, movement,
etc)
Lecture 8-9-10-11/ Spectral properties of LFP [4 hours] – Abhilasha/Eric
- Signal filtering and pre-processing
- Bandpass filtering of neural data
- Power spectral density (PSD) and frequency-domain analysis
- Relating LFP rhythms to behavioural variables
Lectures 12-13-14-15/ Spike–Stimulus Analysis and Decoding [4 hours] –
Eric
- Spike stimulus relationships
- Basic neural decoders
- Clustered decoding approaches
Lectures 16-17-18-19/ Cluster less Decoding Approaches [4 hours] –Eric
- Decoding of continuous variable (eg, spatial position) from spiking activity
- Decoding discrete variables (e.g. value, choice) from spiking activity
- Assessing decoding accuracy and statistical confidence
Analysis project presentation – Abhilasha/Eric
- Final project presentation and assessment
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Course Outcomes |
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After completing this course, the student will be able to: |
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CO1 |
Understand septo-hippocampal-entorhinal circuit anatomy and physiology underlying navigation |
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CO2 |
Visualize and plot neural and behavioural data |
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CO3 |
Analyse spectral properties of local field potentials (LFPs) |
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CO4 |
Decode behavioural or stimulus variables from spiking activity |
Instructors: Abhilasha Joshi, Eric Denovellis
Schedule: Tuesday and Thursday - 10 - 11:30 AM
Venue: LH 2
- Teacher: Abhilasha Joshi